Evaluation of antiepileptic and anti-anxiety activities of Ethanolic extract of Elephantopus scaber leaves

Abstract

The purpose of this study is to investigate the anticonvulsant and antianxiety effects of the ethanolic extract obtained from the leaves of Elephantopus scaber (ETES). In this study, rats were administered with doses of 100, 200, and 300 mg/kg of ETES and their antiepileptic and antianxiety effects were evaluated using experimental animal models. The antiepileptic activity was assessed through the maximal electroshock seizure (MES) test and the Pentyleneterazole (PTZ) induced convulsion assay. The calming effect was evaluated using the elevated plus maze (EPM) and open field test (opt) in rats. Result: in the MES method, the flexion and extensor phases were eliminated. The PTZ method, which involves delaying the onset of PTZ-induced myoclonic jerks, has been found to be effective in managing the condition. In the experiment, all groups that received treatment demonstrated a significant decrease in entries in both the open and closed arms. In option, the number of squares crossed by rats treated with extract decreased significantly. Conclusion: ethanolic extract of Elephantopus scaber (ETES) was found to possess antiepileptic activities however there is less anti-anxiety action in animal models.