A review on chemical composition and pharmacological properties of Murayya paniculata

Abstract

Murraya paniculata is a plant of Rutaceae family comprising over 17 species, which are widely distributed in Asia, Australia, and the Pacific Islands. Furthermore, these species have been used in traditional medicine to treat fever, pain, and dysentery. Several studies have reported extensive use of leaves, seeds, stembark, and bark of Murraya for their natural product composition. Various phytochemical studies have revealed the presence of around 413 compounds of which coumarins, terpenoids, flavonoids, aromatics and alkaloids constitute the largest proportion (46.9%). These isolated compounds have long been known to exhibit different bioactivities, such as cytotoxic and anti-inflammatory properties. Cytotoxic activity has been observed against HCT 116, HeLa, HepG2, and other cell lines. Previous studies have also reported the presence of antifungal, hepatoprotective, antihyperlipidemic, antidiarrheal, and antioxidant effects. Therefore, this review provides a comprehensive overview of Murraya species, highlighting their phytochemistry, biological activities, and pharmacological properties.