Evaluation of sars-cov-2 antibody decay over time following booster dose administration: A prospective observational study

Abstract

Background: Evaluating the decay of SARS-CoV-2 antibodies over time following a booster dose is critical for understanding the longevity and efficacy of COVID-19 immunity. The rate at which antibodies decrease post-booster can vary based on factors like vaccine type, individual health, and age. This study aimed to assess the temporal decay of SARS-CoV-2 antibodies after booster dose administration. Methods: This prospective observational study was carried out at the Department of Biochemistry & Molecular Biology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from March 2022 to February 2023. The study included 80 adult participants aged 25 to 65, who received their COVID-19 booster dose approximately 6–8 months prior. Participants were selected using purposive sampling. Data analysis was performed using SPSS version 26.0. Results: The study found a significant decrease in serum IgG levels when comparing the 6-8 month’s post-booster period to the 3-month measurement, with p-values indicating strong statistical significance (p