A randomized comparative study of nitroglycerine, labetalol and propofol infusion for controlled hypotension during head and neck surgeries

Abstract

Aim: To compare the controlled hypotensive effect of nitroglycerine, labetalol and propofol infusion intraoperatively during head and neck surgery. Material and Methods: The present prospective randomized study was conducted in department of Anaesthesiology & Critical Care, M.M. Institute of Medical Sciences & Research, Mullana after approval from Institutional Ethical committee for a period of 6 months. 105 adult patients between 18 to 65 yeras of age of either sex belongs to American society of Anaesthesiologists (ASA) physical status class I or II, undergoing elective surgical procedure were included in the study. The patients were randomly allocated in following three groups according to hypotensive agents used intra-operatively, using computer generated random number table i.e. Group N: Drug nitroglycine (NTG), Group L: Drug labetalol and Group P: Drug propofol. Results: Duration of anesthesia was maximum in group P followed by N and L with statistically significant difference. The PPI was higher in the labetalol group followed by propofol group and nitroglycerin group at all the intervals, though no significant difference was reported as p>0.05. SFS was modestly lower in the first 20min after drug infusion in the labetalol group compared with the propofol and nitroglycerin group. Subsequent SFS values in all the groups were acceptable (