Circadian rhythms regulated asthma treatment by virtue of pulsatile drug delivery systems

Abstract

The goal of oral pulsatile drug delivery systems (PDDS) is to produce programmed lag phases prior to a rapid, repeatable, or protracted release of medication. They are becoming more and more well-liked as a result of their innate ability to meet chronotherapeutic objectives, which have recently been brought to light in relation to a number of common chronic illnesses marked by recurrent symptoms that typically occur at night or in the early morning (e. g. bronchial asthma, heart attack, rheumatoid arthritis, early-morning awakening). Additionally, when pulsatile delivery systems are appropriately adjusted to prevent unexpected stomach emptying and provide delay times that nearly correspond to the small intestine transit time, time-based colonic release is feasible. Reservoir, capsular, and osmotic devices are among the release platforms that are used for oral pulsatile delivery.