Role of JAK-STAT in pemphigus vulgaris

Abstract

Pemphigus vulgaris is a subtype of autoimmune bullous diseases (AIBDs) that are characterized by flaccid blisters and erosions of skin and mucous membranes with dysregulated immune activity. Autoantibodies binding to desmosomal proteins which is desmogleins (Dsg) 1 and 3 lead to intraepidermal acantholytic blisters in pemphigus diseases. Different factors play a role in immunpathogensis of PV. The complicated mechanisms of immune dysregulation deserve a special attention to study the process and contributors of immune response. The Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway is essential for numerous growth factors (GFs) and cytokines. This signalling pathway is linked to the pathophysiology of several autoinflammatory and autoimmune disorders.