Hypercholesterolemic agents by Aspergillus terreus in solid state and submerged fermentations

Abstract

Hypercholesterolemic agent’s production by Aspergillus terreus indigenous strains in submerged (SmF) and solid state fermentations (SSF) have been studied. To evaluate the ability to produce Hypercholesterolemic agents various cultivation media and substrates have been used. The obtained data showed good yield b Hypercholesterolemic agents A. terreus (1782) and A. terreus 20 both in SmF and SSF. At submerged cultivation of A. terreus 4 and A. terreus 20 on five different glucose and lactose based media the highest titer of Hypercholesterolemic agents or has been obtained on lactose based media, namely 276 mg/l and 236 mg/l, respectively. Five various types of bran have been tested as solid substrates for production of Hypercholesterolemic agents in SSF - wheat bran, oat bran, maize bran, rice bran and mix of wheat and peanut bran. It has been observed that fermentation of A. terreus 4 on wheat and A. terreus 1782 on oat bran causes the highest Hypercholesterolemic agents yield - 9.6 and 9.60 mg/g, respectively.