Giant non-functioning adrenocortical carcinoma: A case report and review of literature

Abstract

Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7–2.0 cases per million individuals annually. It may present with hormonal excess, abdominal mass effects, or incidentally. Here, we report a case of a 39-year-old female with a six-month history of intermittent abdominal pain and weight loss. Imaging revealed a large non-functioning left suprarenal mass measuring 14.2 × 11.9 × 13.7 cm with coarse calcifications and necrosis but no distant metastases. The surgical intervention involved an open left adrenalectomy, and histopathology confirmed high-grade adrenocortical carcinoma with a Weiss score of 6. Postoperative follow-up demonstrated no recurrence. This report underscores the importance of thorough imaging and functional assessment in diagnosing ACC, highlighting surgical resection as the cornerstone of management.