Pharmacological effects of date fruit extracts on neurodegenerative disorders

Abstract

Neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS), are characterized by progressive neuronal degeneration leading to cognitive and motor dysfunction. The search for natural products with neuroprotective properties has intensified, with particular attention on fruits rich in antioxidants and anti-inflammatory compounds. Date fruit (Phoenix dactylifera Linn) extracts, known for their rich phytochemical composition, have shown promise in mitigating oxidative stress and inflammation-two key factors in the progression of neurodegenerative disorders. This paper reviews the pharmacological effects of date fruit extracts on neurodegenerative diseases, highlighting mechanisms of action, experimental findings, and potential applications.