Randomised control trial comparing hemodynamic response of propofol induction 2 mg/kg versus 1.5 mg/kg during endotracheal intubation in general anaesthesia

Abstract

Optimal induction dose administration of intravenous Propofol while maintaining appropriate depth of anaesthesia, stable haemodynamics gives smooth induction and extubation. Bispectral index (BIS) values correlates well with the sedative component in depth of anesthesia by analysing processed EEG signals. A Randomised, double blinded study was conducted on 120 adult patient undergoing elective surgeries under general anaesthesia. Sampling done by Simple Random Sampling using computer generated table with the duration of study of 15 months i.e. from May 2023, to July 2024. Induction dose titration of Propofol while keeping the target depth of anaesthesia is possible with BIS monitoring. In our study, group A patients achieved appropriate depth of anaesthesia with lesser induction dose of intravenous Propofol administration while achieving stable hemodynamics and early recovery.