A comparative study of efficacy of intraperitoneal instillation of injection ropivacaine 0.375% versus placebo on postoperative analgesia for laparoscopic abdominal surgery

Abstract

In laparoscopic abdominal surgeries the cause of pain are of somatic and visceral origin. Somatic pain is due to skin incision and the visceral pain is due to peritoneal distension and visceral irritation caused by creation of capnoperitoneum and surgical handling. Ropivacaine acts by reversible blockade of generation and propagation of action potential in nerves and other excitable tissues at the level of sodium channels. Ropivacaine is long acting amide when given intraperitoneally its action starts in 15-20 minutes and reduces postoperative visceral and shoulder pain following laparoscopic surgeries. A comparative, Randomised study was conducted on 60 adult patients ASA 1 and ASA 2 undergoing elective laparoscopic abdominal surgeries under general anaesthesia for 18 months from Feb 2024 to August 2025 in Basaveshwara Medical college and hospital, Chitradurga, divided into 2 groups of 30 each, Group S - Intraperitoneal instillation with 40 ml of 0.9% normal saline and Group R - with 40 ml of 0.375% Ropivacaine. The mean NRS was <5 till only for 4 hrs in group’s, till 8 hrs in group B, 16 hrs in group R. The duration of analgesia was 137+1.38 hrs in gr R, 7.93+1.44 hrs in gr B and 4.47 +0.86 hrs in gr S.