A comparative study of post-operative hemodynamic stability in patients with intraperitoneal instillation of injection Ropivacaine 0.375% versus placebo on postoperative analgesia for laparoscopic abdominal surgery

Abstract

Pain relief is an important aim of any surgery. Different methods have been proposed to relieve postoperative pain after laparoscopy. These include NSAIDS/opioids, intra peritoneal, and port site infiltration of local anaesthetics, intraperitoneal saline, and use of N20 in place of CO2. Intraperitoneal instillation of local anaesthetics at the end of laparoscopic procedures reduces post-operative pain and lengthens the period of first postoperative analgesia requirement. A comparative, Randomised study will be conducted on 60 adult patients ASA 1 and ASA 2 undergoing elective laparoscopic abdominal surgeries under general anaesthesia for 18 months in Basaveshwara Medical college and hospital, Chitradurga, divided into 2 groups of 30 each, Group S - Intraperitoneal instillation with 40 ml of 0.9% normal saline and Group R - with 40 ml of 0.375% Ropivacaine. The mean of duration of analgesia in Group S was 4.47+0.86 hours, in Group B 7.93+1.44 hours and in Group R 13.47+1.38 hours during the postoperative period. Thus, the mean duration of analgesia in Group R was almost double the duration of analgesia observed in Group B and three times the duration of analgesia observed in Group S. This difference was statistically as well as clinically significant.