A cross-sectional observational study of lipid profile in patients with chronic kidney disease with and without hemodialysis in a tertiary care hospital Mandya

Abstract

Introduction: Chronic kidney disease (CKD), due to increasing frequency and prevalence become one of the leading public health issues. The kidney disease outcome quality initiative (KDOQI)defines CKD as kidney injury or a reduction in glomerular filtration rate (GFR) to <60ml /minute /1.73m2 for at least 3 months. Dyslipidemia is one of the most common complications of chronic renal failure (CRF) reflected even in the early stages of CRF and usually parallels the deterioration in renal function. As a consequence, dyslipidemia as a risk factor in CKD progression should be explored more.Aim of the study: To compare the pattern of lipid profile in CKD patients on conservative management with that of CKD patients on hemodialysis. Methods and Materials: This is a cross-sectional observational study conducted in a tertiary care hospital Mandya after considering inclusion and exclusion criteria. The lipid profile of 100 eligible patients was analyzed using an autoanalyzer. After generation of the proper template, data was entered in Microsoft Excel (Microsoft Corp., Redmond, Washington, United States) and analysis was done through SPSS for Windows, Version 16.0 (Released 2007, SPSS Inc., Chicago, United States). Result: There was a statistically significant decrease in high-density lipoprotein (HDL) and an increase in triglycerides (TG) and very-low-density lipoprotein (VLDL) levels in CKD patients on hemodialysis when compared with CKD patients on conservative management. As far as total cholesterol and low-density lipoprotein (LDL) levels are concerned, they were also significantly increased in CKD patients on hemodialysis than CKD patients on conservative management. Conclusion: Dyslipidemia progresses with the stage of CKD, so early monitoring of lipid profile in CKD patients may help in decreasing the progression of the disease and, hence, mortality in CKD patients.