Microwave-assisted rapid and green synthesis of novel substituted trifluoro schiff bases and their biological evaluation

Abstract

A novel approach for the synthesis of substituted (E)-2-(((3-(trifluoromethyl) phenyl)imino) methyl) phenol (3a-e) were synthesized by the reaction of Trifluoro aromatic aldehyde and aromatic amine using a catalytic amount of Cu-HAP as catalyst under microwave irradiation. This reaction is rapid, efficient, and solvent-free and involves the one-pot synthesis of Schiff bases under microwave irradiation. The catalyst was quantitatively recovered from reaction mixture by simple filtration and reused for three cycles with consistence activity. All these compounds have been characterized by modern spectral techniques such as IR, 1H NMR, Mass etc. Evaluation of synthesized compounds for antimicrobial activity against specific bacterial strains like 1) Escherichia coli 2) Klebsiella pneumoniae 3) Bacillus subtilus 4) Staphylococcus aureus.