Anti-hyperlipidemic activity of ethanol extract of Simarouba amara Aubl in high-fat diet-induced hyperlipidemia in rats

Abstract

Hyperlipidemia is a term that encompasses various genetic and acquired disorders that describe elevated lipid levels within the body. Lipoprotein lipase deficiency (type I a), due to a deficiency of Lipoprotein lipase (LPL) or altered apolipoprotein C2, resulting in elevated chylomicrons, the particles that transfer fatty acids from the digestive tract to the liver is called primary hyperlidimia: Lipoprotein lipase deficiency (type I a), due to a deficiency of Lipoprotein lipase (LPL) or altered apolipoprotein C2, resulting in elevated chylomicrons, the particles that transfer fatty acids from the digestive tract to the liver. There are various medicinal plants has been used for the treatment of hyperlipidemia. In view of this, in present study we have to evaluate Anti-hyperlipidemic activity of ethanol extract of Simarouba amara Aubl in High-fat diet-induced hyperlipidemia in rats. High fat diet induced hyperlipidemia; Male Wistar rats (18-weeks-old), housed in a room maintained at 12 h light–dark cycles and a constant temperature of 22±2 °C, were fed laboratory chow enriched with 2% cholesterol, 1% cholicacid, 20% Dalda and 6% Coconut oil for 4 weeks Hyperlipidemia was confirmed by measuring the levels of serum lipids and lipoproteins in the rats. After 4-week induction of hyperlipidemia the standard drug (Atorvastatin) and test drug (Simarouba amara Aubl ethanol extraction) is treated for two weeks after the experimentation the animals are anesthetized and carried for biochemical and hematological evaluation. The ethanolic extract has shown a significant reduction in serum cholesterol and TGs level indicating anti hyperlipidemic potentials.