Comparative efficacy of two different treatment protocols for treatment of canine transmissible venereal tumour

Abstract

Transmissible venereal tumour (TVT) is usually a sexually transmitted disease of dogs, which mainly affects the external genitalia. Twelve dogs irrespective of sex presented to the small animal unit of VGO, RIVER with history of abnormal bleeding from the external genitalia and confirmed TVT based on microscopic examination of the impression smear were utilized in this study. The dogs were randomly divided into two groups with six animals in each group. In Group I, the dogs were treated with vincristine sulphate @ 0.025 mg/kg BW (I/V) at weekly interval until the dog recover from the condition. In Group 2, along with vincristine sulphate, the dogs were treated with ivermectin @ 200 mcg per kg BW (S/C). The dogs in Group 1 showed progressive improvement after 6 weeks, whereas in case of Group 2, the treatment dose was reduced within 4 weeks of chemotherapy. In conclusion, combination of vincristine and ivermectin was more effective in treating TVT with less number of treatment cycles compared to vincristine alone.