Clinical validation of a Unani pharmacopoeial formulation - Habb-e-Irq un Nisa in Waja‘al-Mafāsil (Rheumatoid Arthritis)

Abstract

Each participant was well informed about the trial and written consent was obtained before initiation of the study. Demographic data and information on the present disease condition, concomitant disease and therapy was recorded. Thorough general physical and systemic clinical examination was carried out. Signs and Symptoms pertaining to Rheumatoid arthritis were recorded in CRF. The vital parameters like blood pressure, heart rate, temperature and respiratory rate were also recorded. Blood sample were collected for the evaluation of laboratory parameters like, complete blood picture, kidney function test, liver function test and routine, microscopic examination of urine and X-Ray of affected joints were done. All clinical and laboratory follow up were done at every 4 weeks.The study was carried out in a total number of 130 patients of Rheumatoid arthritis satisfying the criteria, 90 patients completed the trial. All the patients received treatment with Habb-e-irq un Nisa, out of 90 subjects 43 patients got complete remission, 46 patients got partially remission, 01 patients showed poor remission and 01 patients dropped out. No hepatotoxic and nephrotoxic side effects noticed during the course of study. The clinical and laboratory findings after treatment have shown that Habb-e-irq un Nisa possessed efficacy in the treatment of Rheumatoid arthritis.