Host factors and their impact on the development of periprosthetic joint infections

Abstract

Periprosthetic joint infections (PJI) represent one of the most severe complications following joint arthroplasty, often necessitating complex revision surgeries and prolonged antibiotic therapy. Host factors significantly influence the risk and prognosis of PJI, affecting both the likelihood of infection and the response to treatment. This review explores the impact of various host-related factors, including immunosuppression, comorbidities, obesity, and nutritional status, on the development of PJI, while also discussing emerging strategies to mitigate these risks.