A facile synthesis and antimicrobial activity of erythromycin-2’ester

Abstract

Erythromycin-2’esters were synthesized regiospecifically using some Boc-, Fmoc- and Z protected amino acids. These ester analogs were tested for their antimicrobial activity in vitro against few bacterial strains viz Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae and Escherichia coli taking erythromycin as reference. Some of the compounds synthesized have shown promising antibacterial activity as compared to the reference erythromycin.