Comparative analysis of intraperitoneal ropivacaine with and without tramadol for post-operative pain management in laparoscopic cholecystectomy

Abstract

Aim: This study aimed to compare the postoperative analgesic effect of intraperitoneal instillation of Ropivacaine with and without Tramadol in patients undergoing laparoscopic cholecystectomy. Material and Methods: Sixty-four patients aged 18-60 years were included and randomly divided into two groups: Group R (Ropivacaine alone) and Group RT (Ropivacaine with Tramadol). Pain intensity was measured using the Visual Analogue Scale (VAS) at various intervals postoperatively. Results: The mean VAS scores were significantly lower in Group RT compared to Group R at most time points (e.g., 2 hours postoperatively: Group RT: 2.5±1.2 vs. Group R: 4.0±1.5, p< 0.001). The time to first rescue analgesic was significantly longer in Group RT (226±21.6 min) compared to Group R (100±29.9 min), with a p-value < 0.001. The total analgesic consumption within 24 hours post-surgery was also significantly lower in Group RT (109±47.44 mg) compared to Group R (179±60.19 mg), with a p-value < 0.0001. Conclusion: The combination of intraperitoneal Ropivacaine and Tramadol provides superior postoperative analgesia compared to Ropivacaine alone in patients undergoing laparoscopic cholecystectomy.