Carbetocin vs oxytocin in prevention of PPH during caesarean section

Abstract

Postpartum hemorrhage (PPH) is the leading cause of maternal death worldwide, with uterine atony accounting for 70% of cases. This study aimed to compare the efficacy of carbetocin and oxytocin in preventing PPH during cesarean sections. Conducted at P.C. SETHI hospital in Indore, the prospective comparative study involved 480 women undergoing cesarean delivery with at least one risk factor for PPH. Group 1 received oxytocin, while Group 2 was administered carbetocin. Outcomes, including blood loss, uterine tone, and the need for additional uterotonics, were analyzed. Results indicated that patients receiving carbetocin experienced significantly lower blood loss, reduced need for additional uterotonics, and fewer adverse effects compared to the oxytocin group. Carbetocin was associated with better uterine contractility and lower incidence of uterine atony. The study concludes that carbetocin is more effective than oxytocin for PPH prevention, offering better clinical outcomes during cesarean sections.