Harnessing T-cell responses for effective HIV vaccination

Abstract

HIV remains a global health challenge with significant morbidity and mortality. Despite advances in antiretroviral therapy, an effective HIV vaccine is still lacking. T-cell responses, particularly CD4+ and CD8+ T cells, are crucial in controlling HIV infection and represent a key target for vaccine development. This review examines the role of T-cell responses in HIV infection, evaluates current vaccine strategies focusing on T-cell-mediated immunity, and discusses recent advancements and challenges in harnessing these responses for an effective HIV vaccine.