Clinicopathological comparison between right and left side recurrent colon cancer (local and metastasis)

Abstract

Background: The second leading cause of death in the US is colorectal cancer, which affects both men and women equally. In 2018, the incidence of colorectal cancer in Iraq was third in females 918 (5.13%) and fifth in males 1018 (7.48%). Lower GI hemorrhage, stool changes, abdominal discomfort, weight loss, hunger changes, and weakness are CRC symptoms. Obstructive symptoms are especially concerning. Aim of this study: is to detect the influence of clinicopathological features of tumor site on recurrent of colon cancer. Method: an analytic prospective cross-sectional study of 200 patients with recurrent colon CA who underwent surgical resection of colonic tumor, received treatment, and developed recurrence, dividing the patients into two groups by tumor site (right and left) and analyzing histopathological features and their impact on recurrence. Results: In this study, 200 patients with CA colon were enrolled, with a mean age of 56.5±11.5 years (range 25-86 years), 113 female patients and 87 male patients. Histopathological findings showed that 69% (138) had ulcerating macroscopically feature, 87.5% (175) had moderate grade, 66.5% (133) had T3, and 57% (114) had T4. Conclusion: Recurrence is more common in 6th decade patients, overweight patients, ascending colon patients, ulcerating tumor and moderate differentiated patients, and N1 and stage III patients in the TNM staging system. T3 is the sole significant location of metastasis. Liver and lung recurrence are more likely in right side tumors, but not statistically significant.