Silk based hydrogels in biomedical applications: A review

Abstract

Silk-based hydrogels have emerged as promising materials in biomedical applications due to their excellent biocompatibility, controllable biodegradability, and mechanical properties. These hydrogels, primarily composed of silk fibroin, mimic the extracellular matrix, making them ideal for tissue engineering, wound healing, bone regeneration, and controlled drug delivery. This review explores the preparation methods, properties, and biomedical applications of silk-based hydrogels, highlighting their advantages in promoting cell adhesion, proliferation, and tissue repair. Various cross-linking methods and the incorporation of growth factors or therapeutic agents further enhance the functional capabilities of these hydrogels. The potential of silk fibroin hydrogels in regenerative medicine offers a promising avenue for developing new therapeutic approaches.