The anti-pyretic activity of aqueous and alcoholic extract of stem bark of Neolamarckia cadamba on brewer’s yeast-induced wistar rats

Abstract

The present study investigates the anti-pyretic activity of aqueous and alcoholic extract of stem bark of Neolamarckia cadamba in Wistar rats. Pyrexia was induced by injecting 20% Brewer’s yeast. Pyrexia, or fever, is a common physiological response to infection or inflammation and can lead to various complications if not managed effectively. The study was aimed to explore the potential of Neolamarckia cadamba extracts as a natural remedy for fever management, comparing their efficacy to the standard anti-pyretic drug, Paracetamol. Five groups of Wistar rats were made and administered different treatments. Group T1 served as normal control. Groups T2, T3, T4 and T5, all received 20% Brewer’s yeast at the dosage of 10 ml/kg body weight to induce pyrexia. Group T2 was positive control and received normal saline. Group T3 was administered, Paracetamol at dosage of 100 mg/kg body weight orally, serving as the standard control. Groups T4 and T5 received the aqueous and alcoholic extract of Neolamarckia cadamba at a dosage of 200 mg/kg body weight each, orally. Rectal temperatures were recorded at hourly intervals to monitor the progression of pyrexia and effectiveness of the treatments. Preliminary analysis indicates promising anti-pyretic effects of both Neolamarckia cadamba extracts compared to the standard drug Paracetamol. The study observed a more significant reduction in body temperature in rats treated with the alcoholic extract than aqueous extract, suggesting their potential as alternative or adjunctive therapies for fever management.