Correlation between CRP and APTT in critically ILL children with sepsis

Abstract

Background: Sepsis is associated with a deflection of inflammatory and coagulative parameters, since some clotting factors are known to be involved in the host’s defence against infection and inflammation. These parameters could play a crucial role in the course of sepsis and be used as prognostic markers in critically ill children. Objectives: The present study aims at studying the Correlation between inflammatory marker C-reactive protein and Coagulatory parameter aPTT. Materials and Methods: A total of 300 critically ill pediatric patients diagnosed with sepsis were retrospectively analysed to find out the correlation between C-reactive protein (CRP) and activated partial prothrombin time (APTT) during a time period of six months from 1st July 2023 to 30th June 2024. Results: Logistic regression analysis revealed C-reactive protein and activated partial thromboplastin time (aPTT) to be predictors for survival (p = 0.04 and p = 0.002 respectively). An aPTT prolongation is associated with higher mortality compared to survivors whose aPTT is not prolonged. Conclusion: Non-overshooting aPTT is associated with a higher survival rate in pediatric patients with diagnosed sepsis and whenever there is prolonged aPTT patients are having DIC, septic shock and other clinical comorbidities which increases the mortality.