Correlation of serum PSA level with histopathological findings of prostate specimens in tertiary care hospital

Abstract

Introduction: Prostate cancer is the most common malignancy in men over 65 years of age. PSA is a glycoprotein produced by epithelial cells of prostatic tissue with normal levels of 0-4ng/ml. Increased PSA levels are seen in all prostatic diseases but markedly elevated levels are seen in carcinoma prostate.Aims and objectives• To establish the correlation of histopathological findings with serum prostate specific antigen levels. • To evaluate the histopathological spectrum of non- neoplastic and neoplastic lesions of prostate in correlation of serum PSA level.Methodology: Retrospective study of 120 patients was done in department of pathology, civil hospital, Ahmedabad from 1/10/23 to 30/6/24. Unwilling, inadequate biopsies, metastatic carcinoma and severely morbid patients were excluded. Results: Benign prostatic hyperplasia was the most common lesion with 44.1% followed by carcinoma with 35%. Serum prostate specific antigen level was increased in 76.7% cases. Conclusion: The serum prostate specific antigen levels are a good indicator for the glandular proliferation of prostate. It is a highly sensitive tumor marker with a low specificity as many benign conditions also increase its level. Serum PSA is an early marker for prostate cancer but a more specific test is needed for screening.