Chemical constituents responsible for antiulcer property of leaf extract of Acioa barteri (Hook. F. ex Oliv.) Engl. in Wistar Albino Rats

Abstract

The discovery of a highly effective antiulcer drugs with limited side effects remains a necessity. This study evaluated the anti-ulcer activities of the phytochemicals in ethanol extracts as acioa leaf extracts with Wister albino rats that had been subjected to indomethacin-induced and pylorus-ligated induced gastric ulceration, respectively. Acioa leaf extracts resulted in lower ulcerative index or extent of ulceration in the rat guts, total acidity, acid volume, and higher pH. Similar effects were obtained with ranitidine and Lansoprazole. However, acioa extract dosed at 500 mg/kg concentration gave a better gastro-protective effect than at 250 mg/kg. High Performance Liquid Chromatography, Diode Array Detector identified Gallic acid, Quercetin, Kaempferol, and 3,4,6, tribromo-2-(2,4 dibromophenoxy) phenol as the chemicals responsible for antiulcer activities of acioa leaves. The result demonstrated that acioa leaf extract is a potential anti-ulcer agent.