A case report of mammary carcinoma with pulmonary metastasis in dog

Abstract

Mammary tumors, known as the most frequent malignant neoplasm of intact female dogs, constitute an important problem in Veterinary Medicine. A 9 year-old female, intact Labrador Retriever was brought for post mortem examination. External examination revealed one growth of around 7×4 cm in the right Inguinal mammary gland. After opening the carcass, small white nodular lesion observed on the surface of the lung parenchyma and enlargement of heart. Histopathological examination revealed the presence of proliferating glandular epithelial cells arranged predominantly in a papillary pattern indicating papillary adenocarcinoma. Metastatic Foci of neoplastic epithelial cells were found in heart and lungs. The neoplastic epithelial cells showed positive nuclear expression of the PCNA marker and Cytokeratin (AE1/AE3) in lung and Heart.