Studies on the protective role of Sardinella longiceps extract and quercetin on carbon tetrachloride-induced hematological changes in rats

Abstract

The study aimed to assess the hematological profile of rats treated with Sardinella longiceps extract (SLFE) and quercetin against carbon tetrachloride (CCl4)-induced toxicity. Male Wistar rats (150-200 g) were divided into five groups. The control group received 1% DMSO orally for 3 weeks and olive oil intraperitoneally (i.p.) twice a week during the 2nd and 3rd weeks. Groups II to V were administered CCl4 (1ml/kg b.wt. in olive oil, 1:1) i.p. twice weekly in the 2nd and 3rd weeks. Groups III and IV received SLFE (300mg/kg b.wt.) and quercetin (30mg/kg b.wt.) orally daily for 3 weeks, respectively. Group V was coadministered SLFE and quercetin daily for 3 weeks. CCl4 exposure led to significant reductions (p < 0.01) in hemoglobin, and significant decreases (p