Synthesis and evaluation of dual-target ligands in pain management

Abstract

The management of pain, particularly chronic pain, presents a significant challenge in clinical practice. Traditional analgesics often target a single receptor or pathway, which can lead to limited efficacy and undesirable side effects. Dual-target ligands, which simultaneously modulate two distinct targets, offer a promising approach to enhance therapeutic outcomes and reduce adverse effects. This review explores the synthesis and evaluation of dual-target ligands in pain management, highlighting recent advancements, key methodologies, and clinical implications. Relevant studies are discussed to illustrate the potential and challenges of this innovative strategy.