Exploring polypharmacology in the development of multi-target drugs

Abstract

Polypharmacology, the design or use of pharmaceutical agents that act on multiple targets or disease pathways, represents a promising approach in the development of multi-target drugs. This review explores the principles, strategies, and applications of polypharmacology in drug discovery. We discuss the rationale behind multi-target drugs, the challenges involved, and the innovative approaches being used to identify and develop these agents. The review highlights key studies and examples of successful multi-target drugs, providing insights into their mechanisms and therapeutic potential.