Exploring the chemical space of covalent inhibitors in medicinal chemistry

Abstract

Covalent inhibitors have re-emerged as a powerful class of therapeutic agents in medicinal chemistry, offering advantages such as prolonged target engagement and high potency. This review explores the chemical space of covalent inhibitors, focusing on their design, mechanisms of action, and therapeutic applications. By analyzing recent studies, we provide insights into the development of covalent inhibitors, highlighting successful examples and discussing the challenges and future directions in this field.