Metabolic engineering of yeast for high-yield production of artemisinin

Abstract

Artemisinin, a potent antimalarial compound, is traditionally extracted from the plant Artemisia annua. Due to low yield and high cultivation costs, alternative methods for artemisinin production have been explored. Metabolic engineering of yeast has emerged as a promising approach to produce artemisinin at high yield. This review provides a comprehensive overview of advancements in the metabolic engineering of yeast for artemisinin production. We discuss the biosynthetic pathway, key genetic modifications, optimization strategies, and future perspectives. The integration of synthetic biology and metabolic engineering has significantly improved production efficiency, making yeast a viable platform for large-scale artemisinin production.