The role of heat shock proteins in protein homeostasis and disease

Abstract

Heat shock proteins (HSPs) are a diverse group of molecular chaperones that play a crucial role in maintaining protein homeostasis. They are involved in the folding, assembly, translocation, and degradation of proteins, and their expression is upregulated in response to cellular stress. This review discusses the various functions of HSPs in protein homeostasis, their mechanisms of action, and their involvement in disease processes. The paper highlights recent advancements in understanding HSP biology and explores therapeutic strategies targeting HSPs for treating various diseases.