The contribution of cell cycle dysregulation to metastasis and cancer recurrence

Abstract

Cell cycle dysregulation is a hallmark of cancer, contributing significantly to tumorigenesis, metastasis, and cancer recurrence. This paper explores the mechanisms by which disruptions in cell cycle regulation facilitate cancer progression and metastasis, examining the roles of key cell cycle regulators such as cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors. Additionally, the paper discusses how cell cycle dysregulation contributes to therapeutic resistance and cancer recurrence, highlighting potential therapeutic strategies to target these pathways and improve clinical outcomes.