Exploring the medicinal potential of the mangrove plant Phoenix paludosa: Insights into bacterial anti-biofilm and anti-quorum sensing activities

Abstract

Due to arisen of antimicrobial resistance as a global concern, there is an urgent need for innovative therapeutic approaches. The project aims to isolate and characterize pure constituent(s) from mangrove plants Phoenix paludosa leaves, for evaluating their bacterial anti-biofilm and anti-QS activities, a novel therapeutic approach for tackling multidrug resistance bacteria. The crude ethanolic extract, ethyl acetate and water fractions showed significant biofilm inhibition of Pseudomonas aeruginosa (75.3%, 80.6% & 71.8% inhibition) respectively at the dose of 4mg/ml. In anti-QS activity test, significant percentages of pyocyanin inhibition 77.8%, 70.7% & 69.7% were observed for the above fractions (71.6%, 74.6% and 76.9% inhibition respectively). Pure compound, Trimyristin was isolated from the bioactive ethyl acetate fraction which demonstrated significant biofilm (58.6%), pyocyanin (53.4%), and swarming motility (63.1%) inhibition. This study highlights the potential of P. paludosa leaves as a source for developing novel antibacterial based on anti-QS and anti-biofilm mechanism.