Modulation S100A7 on KC surface and associated immune deflection: Psorolin B ointment

Abstract

The present study describe the effect of Psorolin B ointment in modulating the expression of S100A7 protein by HaCaT cell in cell culture method as well as on human volunteer where the inflammatory reaction was initiated with Capsaicin. Psorolin B application post capsaicin treatment has shown remarkable reduction of S100A7 protein not the capsacin induction post Psorolin B application. The findings suggest that Psorolin B may be effective during pre-inflammatory stage not when the inflammatory reaction has touched the peak. Based on the study finding the treatment recommendation for Psoriasis has been evolved and S100A7 is the protein predominantly invite and elicit the inflammatory events during Psoriasis.