The role of CK19 and CD56 immunohistochemical staining in differentiating papillary thyroid carcinoma from other thyroid lesions

Abstract

Background: The most prevalent thyroid cancer is papillary. PTC's nuclear features are the major diagnostic sign. Due to their localised presence in other thyroid lesions, diagnosis is difficult. The idea is to use CD56 and CK19 (cytokeratin 19) immunohistochemical markers to identify thyroid cancer from similar thyroid lesions. The study aims to determine if CD56 and CK19 immunostains can distinguish papillary thyroid carcinoma from other thyroid lesions that look like it. Methods: Cross-sectional examination of 60 thyroid lesions from April 2022 to November 2023 in AL-Hilla Teaching Hospital, AL-Sadiq Teaching Hospital, and private laboratories discovered immunoexpression of CK19 and CD56. Patients' charts and correlations were investigated. Results: p