New insight about the role of microbiome and probiotics in female reproduction: A review 6

Abstract

Background: The study of the microbiome in regard to human health and disease, particularly in reproductive health, is still a very nascent field of research. This article proposes to enhance understanding of the microbiome of the reproductive tract, that can help improve the handling of reproductive dysfunctions caused by dysbiosis. The disturbance of the microbiota in the uterus and cervico-vaginal area of women has been linked to various gynecological conditions, including polycystic ovary syndrome, endometriosis, non-cyclic pelvic discomfort, and infertility. Global prevalence of female infertility is 12.5%. A novel point of view is arising on the significance of microbiomes of the uterus and vagina especially the context of reproductive health. Recent studies have demonstrated that the targeted use of specific probiotics, often in conjunction with prior antibiotic therapy, can help restore a healthy balance of beneficial microorganisms in the body. This restoration of symbiotic microbiota has been found to enhance the chances of successful conception and improve outcomes in assisted reproductive technology.