Pharmacokinetic modeling of drug metabolism

Abstract

Pharmacokinetic (PK) modeling is a critical tool in understanding drug metabolism and optimizing therapeutic regimens. This study aims to develop and apply pharmacokinetic models to predict drug metabolism, focusing on a model drug. Using in vitro and in vivo data, we constructed compartmental models to describe the absorption, distribution, metabolism, and excretion (ADME) processes. The models were validated with experimental data, demonstrating their accuracy in predicting drug behavior in biological systems. This research highlights the importance of PK modeling in drug development and personalized medicine.