Pharmacological evaluation for anxiolytic and antidepressant effect of Hydroalcoholicroot extract of Caesalpinia pulcherrima in Swiss Albino mice

Abstract

Experience of mental illness is as old as human existence. Studies have reported that anxiety and depression may occur together with the association of sub threshold depressive symptoms. Anxiety may also predispose depression or symptoms of anxiety and depression may be external manifestations of one under cause. Thus, depression and anxiety issues are difficult enough to deal without the added concern of side effects and cost. Herbal extracts is useful in anxiety relief. In preliminary studies of Caesalpinia pulcherrima extracts we identified the enough efficacy for the mental illness. Qualitative studies have shown the presence of carbohydrates, proteins and phenolic compounds in Caesalpinia pulcherrima root extract. The extracts of Caesalpinia pulcherrima roots are very effective on swimming endurance of mice. This investigation was done as described by the previous investigators, using four groups of albino mice and swimming survival time was recorded. In this method, the ant stress effect of extracts was evaluated by determining the improvement in swimming endurance period and overall performance of the animals. This test is widely used to evaluate antistress activity of drugs, since swim endurance reflects physical endurance. Pretreatment with extracts of Caesalpinia pulcherrima have very significantly (p