Interferons and interferon stimulated genes - role in RNA viral infections

Abstract

Interferons and interferon-stimulated genes (ISGs) play a crucial role in the immune response against viral infections. Interferons are signaling proteins that are released by infected cells to alert neighboring cells of the presence of a viral invader. Upon binding to their receptors on neighboring cells, interferons induce the expression of ISGs, which have various antiviral functions. These ISGs can inhibit viral replication, enhance antigen presentation, and activate immune cells to eliminate the virus. Understanding the intricate interplay between interferons and ISGs is essential for developing effective antiviral therapies.