Role of medicinal plant in synthesis of green silver nanoparticles as antibacterial agent

Abstract

In this current era, the fasten antibiotic-resistant of pathogens towards traditional antibiotics, has accountable for major global health problem. Researchers are perceptive to investigate for unconventional non antibiotic antimicrobial agents to control escalating development of bacterial resistance by microorganisms to antimicrobial drugs for prevention of infections caused by resistance pathogens. Different strategies with guiding principles are tested to build up effectual successive antibacterial agents, as widely used traditional physical and chemical methods for the production of NPs are high-cost with along with toxic byproducts, as well as harmful for the environment. In this admiration, green syntheses of nanoparticles are unquestionably promising materials, to reduce the use of hazards chemicals in development of nanoparticles by substituting them with plant-based materials. Silver nanoparticles (GAgNPs) have ability to go through the cell wall by penetrating the membrane of bacteria to amend their virulence potential by interaction with crucial biomolecules making trouble in molecular mechanisms. In fusion with suitable antibiotics, AgNPs may show synergistic effect and help to prevent the increasing worldwide bacterial resistance. Furthermore, due to unique characteristics such as superior biocompatibility and biodegradability GAgNPs have become the researcher’s center of attention of new antibacterial materials due to their small particles, large surface to volume area, physical, mechanical and chemical properties. In this review, we investigated recent studies regarding the potential function of plant extract as a reducing/ capping /stabilizing agent and the antimicrobial activity of AgNPs, their potential for use in the medical and pharmaceutical field.