Hepatoprotective effect of ethanolic extract of Prosopis cineraria seed on CCl4 induced Hepatotoxicity in Albino Rats

Abstract

The ethanol fractions of Prosopis cineraria were subjected to preliminary phytochemical investigation and in-vitro antioxidant activity, the results of phytochemical investigation revealed the presence of carbohydrate, glycosides, flavonoids, tannins and proteins The sample VTRF-1 and VTRF-2 have shown potent antioxidant activity further were investigated for in-vivo antioxidant and hepatoprotective activity against carbon tetrachloride induced hepatotoxicity using biochemical markers. The test drug Prosopis cineraria samples (VTRF-1 & VTRF-2) showed significant hepatoprotective activity against carbon tetrachloride induced hepatotoxicity as evident by restoration of serum transaminases, alkaline phosphatase, bilirubin, triglycerides, cholesterol and protein level. Restoration of lipid peroxidation, glutathione and catalase contents suggests the antioxidant and hepatoprotective activity of VTRF-1, was more potent compare to VTRF-2 ethanol fraction.