Histopathological study of prostatic lesions at a tertiary care hospital, Gujarat

Abstract

Introduction: Prostatitis, benign nodular hyperplasia, and prostatic adenocarcinoma are the common diseases affecting men commonly after their fifth decade. Prostatic tumors are a very important cause of male morbidity and mortality.Aim and Objectives: The objective of this study was to observe the histopathological spectrum of prostatic lesions, to estimate the frequency of various prostatic lesions and to correlate them with demographic and clinical findings.Materials and Methods: A descriptive and observational study was conducted in the department of pathology at Narendra Modi Medical College and Sheth L.G. General Hospital from January 2022 to January 2024.This study was conducted on 50 prostatic specimens received from surgery department.Results: The age of the patients ranged from 43 to 91 years with peak age group of 61-70 years. Transurethral resection of prostate (TURP) was done in 21 (42%) cases, tru-cut core needle biopsy was done in 13(26%) cases and prostatectomy was done in 16 (32%) cases. Out of 50 prostatic specimens received, 44 cases were benign lesions and 6 cases showed prostatic malignancy. All 6 cases of prostatic adenocarcinoma were of acinar type. Gleason score 7 was the commonest score seen in 4 (66.66%) out of 6 cases. All cases of prostatic carcinoma had S.PSA level >10 ng/ml. In present study among all prostatic carcinoma cases, perineural invasion were reported in 3 (50%) cases.Conclusion: Histopathological examination of prostatic lesions plays an important role in diagnosis, management and prognosis of the patients. Early diagnosis and treatment help to reduce mortality and morbidity related to prostatic lesions.