Effect of lemon peel extract gold nanoparticals on neurotoxicity induced by lead and arsenic in wistar rats

Abstract

In Indian system of Ayurveda gold is used in the form of ash (Swarnabhasma) since 800AD mainly as a rejuvenator and its medical indications can be found in all ancient medical classics. Considering therapeutic potential of gold the current study was carried out to evaluate the antioxidant activities of Lemon peel extract gold Nanoparticals (LPGNP) supplement against lead acetate and sodium arsenite –induced nephrotoxicity in wistar rats. In this study, adults male rats were treated for 14 days with lead acetate @ 116.4 mg/kg, Sodium Arsenite (NaAsO2) @ 13.8mg/kg body weight p.o for 14days. Our study showed that supplementation with LPGNP brought improvement in oxidative stress–related parameters (SOD, CAT, Glutathione) and histopathology of brain showed corrective effect of LPGNP on Pb and As -induced brain neurotoxicity. Overall, LPGNP alleviated the toxic effects of these heavy metals on brain tissue, suggesting its role as a potential antioxidant and neuroprotective agent.