Evaluation of the acute and subacute toxicity of Kigelia africana bark extracts on Wistar rats

Abstract

Kigelia africana is a plant present in almost all of Ivory Coast, it has several therapeutic virtues in traditional medicine. For a better use of the bark of this plant we have carried out scientific research. The objectif of this research is to determine the actions of aqueous substances of the bark of Kigelia africana on the hematological and biochemical parameters of female rats. The aqueous substance were obtained by maceration. The results obtained indicated that the substances contain bioactive elements which would give the bark pharmacological properties. The bark of Kigelia africana is safe for health because the LD50 of the products is above 5000 mg/mc. Likewise, the weekly use of extracts revealed their hepato- and cardio-protective activities. A drop in the percentage of urea and creatine in administered rats was observed as well as a gain in the percentage of blood platelets in the treated rats. These results show that these bark extracts did not generate any damage during the study period at the different doses studied.