Investigation of neonatal seizure activity of clinical and biochemical profile survey at tertiary care center

Abstract

Background: Neonatal seizures are a common and easily identifiable clinical manifestation of a malfunctioning brain system. The objective of the study is to utilize clinical criteria to diagnose neonatal convulsions and ascertain the presence of biochemical abnormalities. Methods: An innovative study methodology focusing on neonates admitted to hospitals. This study identified the prevailing metabolic anomaly in neonates. The study was carried out at the pediatrics department of Madha Medical College, located in Chennai, Tamilnadu, India. The study was conducted from September 2018 to August 2019. Neonates who satisfied the specified criteria for inclusion and exclusion and were subsequently admitted to the Neonatal Intensive Care Unit. Results: In my study, male babies accounted for roughly 59% of the cases of neonatal seizures, while female newborns accounted for approximately 41%. The male to female ratio was around 1.25:1. Another study conducted by Tekgul et al. demonstrated a male to female ratio of 1.15:1, while Sudia et al. reported a male to female ratio of 1.73:1. These findings support my study's conclusion that seizures are more prevalent in males. My study involved the delivery of 44 babies through vaginal birth, 44 kids through Caesarean sections, and 12 babies with the use of forceps. Conclusion: Based on this investigation, it may be inferred that biochemical abnormalities may be the main or secondary problem. Temporary anomalies have a favorable prognosis and can be easily treated. Early treatment of metabolic problems improves the prognosis and outcome of the newborn, preventing neurological ramifications.