Effect of methanolic and ethyl acetate extracts of the rhizomes of Curcuma mangga acclimated to Congo on the production of reactive oxygen species (ROS)

Abstract

The effect of extracts from acclimated C. mangga rhizomes from Congo on the production of reactive oxygen species (ROS) was evaluated on leukocyte cells obtained by hemolysis of human blood. Two types of extracts were tested, the methanolic extract and the ethyl acetate fraction. The results show that both extracts significantly reduce the production of ROS. However, the extract obtained with ethyl acetate is more active with an inhibition percentage of 63%, compared to the methanolic extract which inhibits it by up to 55%. This significant activity of the ethyl acetate extract would be linked to the major compounds identified in this extract, namely Zerumin A and (E)-labda-8(17), 12-dien-15, 16- dial.